Bioresorption Control and Biological Response of Magnesium Alloy AZ31 Coated with Poly-β-Hydroxybutyrate

Magnesium and its alloys are not normally used as bioresorbable temporary implants due to their high uncontrolled degradation rate in a physiological liquid environment. The improvement of corrosion resistance simulated body fluids (SBF) magnesium alloy (AZ31) coated with poly-β-hydroxybutyrate (PHB) was investigated. Scanning electron microscopy, Fourier transform infrared spectrometer, contact angle measurements were characterize surface morphology, material composition, wettability, respectively. pH modification the SBF corroding medium, mass Mg2+ ions released, weight loss samples exposed solution, electrochemical experiments describe process kinetics. material’s biocompatibility described by evaluating effect products collected equilibrating solution on hemolysis ratio, cytotoxicity, nitric oxide (NO), total antioxidant capacity (T-AOC). results showed that PHB coating can diffusively control alloy, improving biocompatibility: materials lower than 5%, while vitro human umbilical vein endothelial cell (HUVEC) compatibility PHB-coated Mg promoted proliferation had no NO content T-AOC enhanced compared normal group bare AZ31 alloy. extraction have less toxic behavior concentration byproducts deriving from diffusion exerted films both metal vice versa. These findings provide more reference value for selection such systems tunable prosthetic materials.